Utilization of Transmission Electron Microscopy to Visualize Skeletal Muscle Damage Following Injurous Downhill Running in Mice

This study is the first to utilize electron microscopy to quantify skeletal muscle damage in mice following injurious downhill running. Downhill running naturally implements damaging eccentric contractions in the triceps muscles in mice. Skeletal muscle damage was found twenty-four hours following injury and ranged from mild to severe in sarcomeric disruption.