Serum Concentrations Of Protein S100B And The Menstrual Cycle

One group of men and two different groups of women, all between the ages of 18-30 will be recruited for this study. The two experimental groups will consist of women who may or may not be using a form of contraception that does not alter normal menstruation and have not had a concussion within the past six months. The control group will be men who have not suffered from a concussion within the past six months. A blood sample during the early follicular (menses), late follicular (ovulation), and mid-luteal phases of the menstrual phase will be obtained from the two experimental groups. The control group will be tested three times over a similar 28-day cycle. An Enzyme-linked Immunosorbent Assay (ELISA) will be run on the blood to determine the concentration of S100B and Estrogen at each phase of the menstrual cycle. A one-way analysis of variance (ANOVA) was used in measuring S100B among the different sample groups, and a repeated measures ANOVA was used to analyze the relationship within groups of S100B concentrations to the menstrual phases.