Influence Of Oncolytic Vesicular Stomatitis Virus On Macrophage Phagocytosis And Breast Cancer Cell Growth In Coculture

This study tested the hypothesis that oncolytic vesicular stomatitis virus could reprogram tumor-promoting M2 THP-1 macrophages into an M1 population capable of suppressing the growth of triple-negative breast cancer cells. While evidence of virus-dependent macrophage reprogramming could be seen via the significant reduction in phagocytosis of latex beads, the growth suppression effects could not be determined in our breast tumor microenvironment-simulating coculture conditions. This was because MDA-MB-231 breast cancer growth was blocked by infection with both wild-type (rwt) and mutant (rM51R-M) VSV strains at all infection ratios tested. These results underscore the substantial oncolytic effects of VSV on an aggressive breast cancer subtype.