Developmental Expression Pattern Of The zgc:154061 Gene In Zebrafish

The zgc:154061 gene has been identified in the genomes of all vertebrates examined to date. It is organized in a convergently transcribed orientation relative to Meis2 (meis2.2 in zebrafish) and is also in the region of at least one Highly Conserved Non-coding Element (HCNE) hypothesized to be involved in controlling Meis2 and/or zgc:154061 expression. This conformation and organization is highly conserved amongst all vertebrates. The conservation of this genomic proximity of zgc:154061, Meis2, and the HCNEs over the hundreds of millions of years of evolution of vertebrates indicates that the components of this region of synteny are linked and serve an important function.